Newrotex’s initial product is SilkAxons® luminal spider silk fibres that can be implanted into a vein or hollow conduit to allow effective long-length nerve repairs.
There exists strong preclinical data for silk. Multiple animal trials show that silk fibres from spiders exhibit equivalent or superior axonal regeneration compared to autografts. Our first-in-human clinical trial preliminary data also supports this.
Harvested from Nephila spiders our luminal silk fibres can be implanted inside a vein or hollow conduit to support nerve re-growth. These silk fibres mimic the natural ‘Bands of Büngner’, providing an excellent scaffold for nerve regeneration.
Our first product is a 10cm implant which can be used for large nerve gap repairs (or shortened for use in smaller gaps).
Our solution allows the intraluminal distribution of fibres without excessive material for the regenerating nerve to have to break down. This dramatically improves the efficacy when performing long-gap peripheral nerve repairs.
Our luminal silk fibres are available in any length or diameter to match the damaged nerve. They can be used to repair small nerves, such as with oral and maxillofacial surgery (OMFS) and urology, or large nerves as found in cases of trauma, cancer resection, and breast neurotisation.
Finally, Newrotex luminal silk fibres are easily combined with existing techniques and regulatory-approved devices expanding its indications for use.
Our secondary product is an off the shelf silk conduit containing SilkAxons®. This product provides surgical ease, negating the need to thread the implant through a vein. The simplicity of the surgical techniques required to implant this off-the-shelf device will make it widely accessible to surgeons of all disciplines. This in turn will improve patient outcomes due to the proven correlation between efficacy and time to treatment.
There are many benefits to using our filled silk tubes for axon regrowth and peripheral nerve repair, including but not limited to the following:
Completely biodegradable
Capable of large gap repair (according to pre-clinical data)
Reduces surgery times and overall procedure costs
Excellent scaffold for nerve regeneration
Length and diameter can be adjusted to match the damaged nerve
Greatly shortened recovery time reduces socioeconomic burden
Inexpensive and easy to store, package, and delivery
Readily available for use in all hospitals by any surgical speciality
Mitigates unforeseen costs, including from complications with nerve autograft procedures
There is strong preclinical data for silk applications from studies showing both fibres and conduits made from silk to be effective for peripheral nerve repair. Newrotex has conducted animal trials and is now conducting a first-in-human clinical study on large-gap nerve repair.
Read the Trials page for more details on the preclinical data and Newrotex’s clinical trials.
Newrotex aims to improve aspects of surgical nerve repair for all parties involved in the process.
For patients, it means improving outcomes and eliminating the need for harmful autograft procedures.
For surgeons, it means fewer complications by employing repeatable, simple techniques and shorter operating times.
For hospitals and national buyers, it means reducing the costs associated with patient morbidity, theatre usage, storage, and supply.
We strive to use our silk technology to help patients suffering nerve injuries due to trauma, cancer surgery, as well as those undergoing breast reconstruction, oral and maxillofacial surgery (OMFS), and urological procedures.
Our long-term outlook includes progressing our silk platform technology, which is already under development for use as organoids for pharmaceutical testing, as a drug delivery system, and in central nervous system (CNS) repair.
Learn more about our products, facilities, and key people on our About Us page.
